Advancing Sexual and Reproductive Health and Rights
 
Family Planning Perspectives
Volume 27, Number 2, March/April 1995

Using Induced Abortion to Measure Contraceptive Efficacy

By Finn Egil Skjeldestad

Data from a 1989-1990 case-control study of contraceptive efficacy in Norway compare contraceptive use among women who requested an abortion (1,386 cases) with women who responded to a general fertility survey (2,627 controls). In a logistic regression analysis measuring contraceptive efficacy as the odds of avoiding a pregnancy that terminated in an induced abortion compared with the odds for nonuse, consistent condom use was found to lower fecundity by 88.9%, diaphragm use by 89.3%, the pill by 97.8%, the IUD by 97.6%, vasectomy by 99.5%, and female sterilization by 99.8%. The relative contraceptive efficacy of the condom, the IUD and the pill did not vary by marital status or parity but did vary with age; the proportion by which each of these methods reduced fecundity declined among successively older age-groups.

(Family Planning Perspectives, 27:71-73 & 96, 1995)

In Scandinavia, the widespread availability of modern contraceptives at little or no cost is reflected in high rates of contraceptive use and low rates of induced abortion.1 However, Scandinavian women still experience unplanned pregnancy, and many become pregnant while using methods with high efficacy rates.2

Contraceptive efficacy rates are usually presented as failure rates per 100 woman-years of use, with distinctions made between method and user failures. However, from the user's point of view, a contraceptive failure is always experienc ed as an unplanned pregnancy, whatever its reason. When studying the efficacy of a specific method prospectively, different types or formulations of the same method are usually compared;3 a direct comparis on between methods is almost impossible to do prospectively because of ethical considerations, problems of compliance when women are randomly allocated specific methods, and problems of sufficient sample size.4

The present study uses a case-control approach to compare the contraceptive experience of women who sought an induced abortion (the cases) with that of women who responded to a general Norwegian fertility survey (the controls). As such, the outcome measure is not an incidence rate, but the relative reduction in fecundity provided by use of a specific contraceptive method compared with nonuse.

METHODOLOGY

All women who terminated a pregnancy from January 1989 through December 1990 at the Department of Gynecology, University Hospital of Trondheim, Norway, served as cases. This is the only hospital in the city and has a catchment area of 250,000 inhabitants.Approximately 85% of all abortions induced annually in the county are performed by the department.

Precoded medical records data, which have been collected for all pregnancy terminations since 1983, include information on the woman's age, marital status, parity, previous abortion history, contraceptive use at the time of conception, and recommendations for future contraceptive use. Clinical data are also entered into the records. The year of birth for cases ranged from 1942 to 1974. So that cases were of approximately the same age range as controls, only women born between 1943 and 1968 were included i n the analysis. Thus, there were 1,386 women (aged 20-45) who terminated a pregnancy at the department over the study period for whom complete data were available.

Participants in the 1988 Norwegian fertility study, the Family and Occupation Survey, served as controls. The survey was based on interviews from a stratified random sample of 4,933 women aged 20-43 selected from Norway's Central Population Registry. The full control group was drawn from the five-year cohorts for the midpoint years 1945, 1950, 1955, 1960, 1965 and for the single year 1968. The procedures used for selecting the sample are more fully described elsewhere.5

Women were interviewed in their homes between October 1988 and August 1989 by the regular interview staff of Statistics Norway, which conducted the survey. The response rate was 81%, which yielded a final sample size of 4,019 women. The mean age of nonrespondents did not differ from that of respondents; however, there were more older childless women and a larger proportion of previously married women among nonrespondents than among respondents.6

So only women in need of contraception were in the control group, we excluded those who had never had sexual intercourse (N=151), those who had not been sexually active in the four weeks preceding the interview (N=644), those who were infecund (N=177), those who were pregnant (N=187), and nonrespondents to the specific sexual activity or contraceptive use questions (N=78). Moreover, women who were not practicing contraception were excluded if they wanted to become pregnant within the n ext two years (N=155). These exclusions left a total sample of 2,627 women (65% of the original sample) who could be defined as fecund, sexually active and not currently planning a pregnancy.

Current contraceptive use was defined as the method used at the time of conception among the cases and the method (or methods) used in the month preceding the interview among the controls. Women who used more than one method were classified according to the method known to be more effective in preventing pregnancy, using the following ranking—female sterilization; male sterilization; the pill; the IUD; the diaphragm; the condom; foam, rhythm or withdrawal; and others.7

Method use was clinically confirmed among the 102 cases who became pregnant while using an IUD, since the device was removed by either the physician who referred the woman for the abortion or by the gynecologist who performed it. For the three sterilized women who became pregnant, confirmation of the operation was made by checking the hospital's medical records. Checking the medical records of the referring doctors confirmed that the pill had been prescribed in three-fourths of the 184 cases who said that they were taking the pill when they conceived. However, evidence of a prescription is not proof that a woman was using the pill at the time of the conception. Three cases stated that their husbands were sterilized; however, whether the husband had received a vasectomy, or whether he really was the father, could not be validated.

A logistic regression model* was used to estimate the relative odds of contraceptive failure among the users of different contraceptive methods, with pregnancy termination being the dependent variable. The probability of pregnancy among contraceptive users (i.e., of condoms, pills, the IUD and female sterilization) was compared with that among nonusers, expressed as adjusted odds ratios with 95% confidence intervals. One minus the adjusted odds ratio was interpreted as the estimate of the reduction in fec undity associated with the typical use of each method.

The model controlled for age, marital status and parity. A stepwise logistic regression approach was applied in the model-building. Variables that had a univariate chi square p-value of <.25 were considered as candidates for the multivariate model. The likelihood ratio test for the differences between models, with or without the specific variable, was used to identify the best fit (p<.05).8 Use of each method was compared separately with nonuse.

The presence of an interaction, which implies that the effect of one of the variables is not constant with respect to changes in the levels of others, was tested according to prior knowledge of how contraceptive use differs by marital status, parity and age (only first degree interaction terms), with statistical significance set at p<.01. Interaction between marital status, parity and age per se was not tested. An interaction between contraceptive use and a specific confounding variable's effect on the dependent variable was tested at the time the confounding variable appeared in the model.

RESULTS

Table 1 presents the demographic and contraceptive use characteristics of women having abortions and all women. Compared with all women, those having abortions were more likely to be young, single and to never have had children or to have had only one child. Well over half (57%) of women having abortions were not using any method at the time of conception, while less than 5% of the general population were not using a method in the month preceding the survey.

Table 1. Percentage distribution of women who obtained an induced abortion and of women who responded to a general Norwegian fertility survey, by characteristic, 1988-1990
Characteristic Obtained abortion (N=1,386) General population (N=2,627)
Age
20-24 35.7 30.5
25-34 45.8 35.7
35-44 18.5 33.8
Marital status
Single 52.0 19.4
Married or cohabiting 48.0 80.6
Parity
0 or 1 62.5 46.7
>=2 37.5 53.3
Contraceptive use*
None 56.5 4.3
Natural methods 2.8 5.8
Condom 22.7 16.4
Diaphragm 0.9 0.5
IUD 6.6 27.8
Pill 10.0 28.4
Vasectomy 0.2 4.3
Female sterilization 0.2 12.5
Total 100.0 100.0
*Among women obtaining an abortion, method used at time of conception, and among general population, method used in the month before the interview.

Table 2 presents the proportion by which reliance on each specific method reduced fecundity in comparison with nonuse. For example, consistent reliance on the condom, or the diaphragm, reduced fecundity by 89%, compared with nonuse. The percentage by which condom use lowered fecundity compared with nonuse did not vary by women's marital status and parity, but decreased with age, going from 95% among 20-24-year-olds to 86% among 25-34-year-olds, and to 79% among 35-44-year-olds.

Table 2. Percentage reduction in fecundity among contraceptive users compared with nonusers and 95% confidence intervals, by method and age-group
Method and age-group % reduction in fecundity 95% C.I.
Condom 88.9 85.7-91.5
20-24 94.9 91.6-96.9
25-34 85.8 78.8-90.6
35-44 78.9 65.0-87.1
Diaphragm 89.3 73.3-95.7
IUD 97.6 96.7-98.3
20-24 98.8 97.2-99.5
25-34 98.3 98.1-98.9
35-44 96.2 93.5-97.7
Pill 97.8 96.9-98.4
20-24 99.0 98.3-99.4
25-34 96.0 93.7-97.4
35-44 92.0 79.2-96.9
Vasectomy* 99.5 96.8-99.9
Female sterilization 99.8 99.4-99.9
*Among married and cohabiting women only.

Women who relied on the pill or the IUD had a nearly 98% reduction in fecundity, compared with women who used no method. As with the condom, the estimates were consistent regardless of marital status or parity, but decreased with age. Women who had been s terilized experienced a 99.8% reduction in their fecundity compared with nonusers. Reliance on vasectomy relative to no method (calculated among married and cohabiting women only) reduced fecundity by 99.5%.

Data on the preventive effect of natural methods of family planning could not be presented because one-fifth of these users relied on more than one method. Of the 152 women in the general population survey who relied on natural methods, for example, 31 sa id they used both periodic abstinence and withdrawal in the month before the survey.

DISCUSSION AND CONCLUSIONS

Our understanding of the relative efficacy of different contraceptive methods is limited by research design problems and because the analytic tools to adequately assess relative efficacy are lacking.9 A population-based, case-control approach such as the current study, which uses abortion as the measure of contraceptive failure, can compare the effectiveness of different contraceptive methods. The outcome measure will not be the incidence of contraceptive failure per 100 woman-years of use, but the relative reduction in fecundity for a particular contraceptive method in comparison with nonuse.

The results of an analysis that uses abortion as a proxy for unintended pregnancy, however, may overestimate or underestimate a method's efficacy, depending on the distribution of pregnancy outcomes among nonusers and those who experience a contraceptive failure. That is, if nonusers are more likely than users to terminate their pregnancies, then method efficacy will be overestimated; but if nonusers are more likely to carry their pregnancies to term, the efficacy estimates will be underestimated.

To assess this form of selection bias, contraceptive data were reanalyzed from a 1983 study of 399 pregnant women aged 20-44 that examined the influence of social and demographic factors on how unplanned pregnancies were resolved.10 After the data were adjusted for marital status, parity and age, nonusers were more likely than users to decide on abortion. In Norway, the ratio of induced abortions to births stayed relatively constant between 1983 and 1988-1989.11 Thus, any bias created by using abortion as a proxy for unintended pregnancy would be toward underestimating reductions in fecundity.

Of course, women who choose to terminate a pregnancy caused by a contraceptive failure represent only a subset of all women who have experienced a contraceptive failure. If method use among women choosing pregnancy termination were similar to that among w omen carrying to term, then the estimate of contraceptive efficacy would be a "true" one. However, if the use of one particular method is overrepresented among women who choose abortion, the efficacy estimate for that method would be biased toward the nul l hypothesis (underestimated). Conversely, if use of specific methods is underrepresented among women seeking abortions, the estimates for such methods would be biased away from the null hypothesis (overestimated). This situation occurs when proportionate ly more contraceptive users who experience a method failure carry their pregnancies to term.

The variation in age-specific efficacy estimates for users of the condom, the pill and the IUD illustrates this selection problem. According to data from the 1983 study, younger users of these methods (sample sizes were not large enough to analyze each me thod separately) were more likely than older users to choose to carry a pregnancy resulting from contraceptive failure to term;12 this bias results in higher efficacy estimates among women in younger age-groups. Conversely, since older users were more likely to choose abortion, their efficacy estimates would be lower. Thus, the interaction in the current study between contraceptive efficacy and age can be explained by variation in pregnancy outcome choic e by age, rather than by any variation in sexual activity by age.

Another earlier Norwegian study on the outcomes of pregnancies that occurred with the IUD in situ showed that proportionately more pregnancies were terminated than carried to term.13 This indicates that the contraceptive effectiveness associated with the IUD might be higher than that found in this study.

As mentioned earlier, the fact that the pill had been prescribed by the referring physician was confirmed for 75% of the cases who claimed they became pregnant while taking the pill. However, it was impossible to validate pill use among women in the contr ol group. In general, women who choose the pill are younger and have fewer children than those who select the IUD.14 These differences might affect decisions regarding pregnancy outcome and explain the i nteraction between age and contraceptive efficacy that was found in the current study for the pill.

Pregnancy after a sterilization will always be a method failure, unless the woman was pregnant at the time of sterilization. An examination of the medical records of the three cases who said they had been sterilized uncovered no complications or discrepan cies in operation procedures. The efficacy estimate for female sterilization would seem to be valid, since the data conform to the method's low clinical rate of failure.

Three of the 13 diaphragm users who became pregnant combined use of the diaphragm and the condom, thus limiting the ability to analyze a pure diaphragm effect; the simultaneous use of both methods will overestimate the effect of the diaphragm alone. This analysis found no major difference in efficacy estimates between the condom and the diaphragm.

Natural methods of birth control were excluded because of a tendency among users to use more than one method and because we suspect that if pregnancy occurs, women relying on periodic abstinence or withdrawal are likely to report that they were not using any method at the time of conception. If the latter speculation is true, reliance on natural methods is effectively underreported. This will bias the results away from the null hypothesis, and thus overestimate the contraceptive effectiveness of such meth ods.

As mentioned earlier, this analysis used data on women who sought an abortion at the University Hospital of Trondheim, where 85% of abortions in the county take place. Data were also examined from women who sought an abortion during a two-month period in 1990 at the other county hospital where the remaining 15% of abortions are performed. 15 There were no differences in patterns of contraceptive use between the abortion patients in the two hospitals over the same two-month period. Therefore, it is unlikely that a skewed selection of cases has biased the efficacy estimates.

Data on the control group were collected during the fall of 1988 through the spring of 1989 from a representative sample of women from all over Norway. Patterns of contraceptive use among women interviewed for this survey who lived in the county did not d iffer from those among women living elsewhere in Norway. The women who comprised the cases—those who sought an abortion at the University Hospital of Trondheim—are representative by age of all women who sought an abortion in Norway in 1989 and 1990.16 Thus, data on contraceptive efficacy from the current study may be valid for Norway in general.

As the need for contraception is dependent on sexual activity, the reduction in fecundity associated with specific methods will also be dependent on the frequency of intercourse. Norwegian studies of sexual activity carried out in 1987 and 1988 indicate t hat married and cohabiting women had intercourse significantly more frequently than did single women.17 However, the current study found no interaction between marital status and contraceptive efficacy.

Nearly two-thirds of Norway's female population of reproductive age is sexually active and fecund, and potentially in need of contraception; about 2% of these women have an abortion each year. 18 About 60% of the abortions occur among the approximately 5% of all women who do not practice contraception; the other women having a pregnancy termination come from the 95% of the population of sexually active females at reproductive age who are using a method. T hus, shifting reliance from less effective methods (i.e., natural family planning, condoms and the diaphragm) to more effective methods (the pill and the IUD) will not affect the magnitude of the abortion rate to any significant extent. Switching from non use to consistent use of a less effective method such as the condom, or to use of any of the more effective methods, would have a substantial effect on the abortion rate.

The great majority of pregnancies that occur to the 5% of Norwegian women who do not use any method, however, lead to a live birth.19 As the overall ratio of births to induced abortions has remained at 4:1 for many years, improved contraceptive practice would more likely lead to a marked reduction in births, particularly among married and cohabiting women who are less likely to terminate an unplanned pregnancy than are single women.

References

1. F.E. Skjeldestad, "Choice of Contraceptive Modality by Women in Norway," Acta Obstetricia et Gynecologica Scandinavica, 73:48-52, 1994; K. Makkonen and E. Hemminki, "Different Contraceptive Practices: Use of Contraceptives in Finland and Other Nordic Countries in the 1970s and 1980s," Scandinavian Journal of Social Medicine, 19:32-38, 1991; M. Osler and F.E. Riphagen, "Contraception Survey: Denmark 1988," Contraception, 42:507- 521, 1990; F.E. Riphagen and B. von Schoultz, "Contraception in Sweden," Contraception, 39:633-642, 1989; and S.K. Henshaw, "Induced Abortion: A World Review," Family Planning Perspectives, 22:76-89, 1990.

2. F.E. Skjeldestad et al., "Prevensjonsbruk blant abortsøkende kvinner" (Contraception Among Women Seeking Abortion), Journal of the Norwegian Medical Association, 108:207-209, 1988; K. Sidenius et al., "Abortsøkende kvinders konceptionsvaner" (The Contraceptive Habits of Women Applying for Termination of Pregnancy), Journal of the Danish Medical Association, 145:3721-3724, 1983; and S.K. Henshaw and J. Silverman, "The Characteristics and Prior Contraceptive Use of U.S. Abortion Patients," Family Planning Perspectives, 20:158-168, 1988.

4. J. Trussell et al., "A Guide to Interpreting Contraceptive Efficacy Studies," Obstetrics and Gynecology, 76:558- 567, 1990; K Steffensen, "Evaluation of an Oral Contraceptive Containing 0.150 mg Desogestrel and 0.020 mg Ethinylestradiol in Women Aged 30 Years or Older," Acta Obstetricia et Gynecologica Scandinavica, Supplement, 144:23-27, 1987; S.L. Corson, "Efficacy and Clinical Profile of a New Oral Contraceptive Containing Norgestimate," Acta Obstetricia et Gynecologica Scandinavica, Supplement, 152:25-31, 1990; H. Bratt et al., "A Randomised Trial of Three Copper IUDs," Acta Obstetricia et Gynecologica Scandinavica, 67:247-251, 1988; and T. Luukkainen et al., "Five Years' Experience of Intrauterine Contraception with the Nova-T and Copper-T 200," American Journal of Obstetrics and Gynecology, 147:885-892, 1983.

6. J. Trussell and K. Kost, "Contraceptive Failure in the United States: A Critical Review of the Literature," Studies in Family Planning, 18:237-283, 1987.

8. Family and Occupation Survey, 1988, Central Bureau of Statistics of Norway, Oslo, 1991.

10. Ibid.

7. W.D. Mosher, "Contraceptive Practice in the U.S., 1982-1988," Family Planning Perspectives, 22:198-205, 1990.

14. D.W. Hosmer and S. Lemeshow, Applied Logistic Regression, John Wiley & Sons, New York, 1989.

16. J. Trussell, "Methodological Pitfalls in the Analysis of Contraceptive Failure," Statistics in Medicine, 10:201-220, 1991.

18. F.E. Skjeldestad, "When Pregnant—Why Induced Abortion?" Scandinavian Journal of Social Medicine, 22:68- 73, 1994.

20. F.E. Skjeldestad et al., "Induced Abortion: Effects of Marital Status, Age and Parity on Choice of Pregnancy Termination," Acta Obstetricia et Gynecologica Scandinavica, 73:255-260, 1994.

22. F.E. Skjeldestad, 1994, op. cit. (see reference 10).

24. F.E. Skjeldestad et al., "Outcomes of Pregnancy with an IUD in Situ: A Population Based Case-Control Study," Advancement of Contraception, 4:265-270, 1988.

14. F.E. Skjeldestad., 1994, op. cit. (see reference 1).

28. F.E. Skjeldestad, unpublished data on contraceptive use collected as part of survey on Chlamydia trachomatis screening among women seeking abortions in Norway; and F.E. Skjeldestad and F. Jerve, "Chlamydia Trachomatis and Neisseria Gonorrhea Among Women Seeking Abortion in Norway," Journal of the Norwegian Medical Association, 112:2082-2084, 1992.

16. Weekly Report, No. 11, Statistics Norway, 1990; and Weekly Report, No. 13/14, Statistics Norway, 1991.

32. L.S. Bakketeig and B. Hareide, Rapport fra seksualvaneundersøkelsene i 1987 og 1992 (Report of the Surveys of Sexual Habits in Norway, 1987 and 1992), Folkehelsa, Oslo, 1993.

34. F. E. Skjeldestad and J.-K. Borgan, "Trends in Induced Abortion During the 12 Years Since Legalization in Norway," Family Planning Perspectives, 26:73-76, 1994.

19. F. E. Skjeldestad, 1994, op. cit. (see reference 1).

Finn Egil Skjeldestad is a lecturer in the Department of Gynecology and Obstetrics, University Hospital of Trondheim, Trondheim, Norway.Using Abortion to Measure Contraceptive Efficacy*Statistical analyses were performed with the Statistical Packag e for the Social Sciences, version 4.1.