The Guttmacher-Lancet Commission on Sexual and Reproductive Health and Rights launched its groundbreaking report on May 9th at Constitution Hill in Johannesburg, South Africa. The event featured an opening plenary consisting of Dr. Manala Makua, Director of Women’s Health and Genetics at the National Department of Health of South Africa; Dr. Julitta Onabanjo, UNFPA Regional Director, East and Southern Africa; Richard Horton, editor-in-chief of The Lancet; and Commission cochairs Ann Starrs and Dr. Alex Ezeh and was moderated by Kgomotso Matsunyane. Following a presentation of key findings and recommendations from Commission cochairs Ann Starrs and Dr. Alex Ezeh, a panel of leading health, rights and legal experts then discussed the implications of the Commission’s agenda for health, development, human rights and the specific needs of key populations. The panel consisted of Lebogang Ramafoko, Executive Director and CEO of Soul City; Phindi Sithole-Spong, sexual health advocate; Justine Edwin Cameron of the Constitutional Court of South Africa; and Dr. Barbara Klugman, legal advocate.